Research

Publications

Academic research and scientific contributions by Dr. Felix Effah

E-cigarette Research

46 citations
Pulmonary effects of e-liquid flavors: a systematic review
Journal of Toxicology and Environmental Health, Part B 25 (7), 343-371 (2022) | Effah F, Taiwo B, Baines D, Bailey A, Marczylo T

Summary

A comprehensive systematic review examining how different e-liquid flavors affect lung health, providing critical insights for public health policy and e-cigarette regulations.

8 citations
In Vitro high-throughput toxicological assessment of E-cigarette flavors on human bronchial epithelial cells and the potential involvement of TRPA1 in cinnamon flavor-induced toxicity
Toxicology 496, 153617 (2023) | Effah F, Elzein A, Taiwo B, Baines D, Bailey A, Marczylo T

Summary

This research evaluates the toxicity of various e-cigarette flavors on human lung cells, with special focus on how cinnamon flavoring may cause harm through specific cellular pathways.

Neuropharmacology

17 citations
Dynamic changes in the endocannabinoid system during the aging process: focus on the middle-age crisis
International Journal of Molecular Sciences 23 (18), 10254 (2022) | Nidadavolu P, Bilkei-Gorzo A, Effah F, Leidmaa E, Schürmann B, et al.

Summary

This study investigates how the endocannabinoid system changes throughout the aging process, with particular attention to middle age, revealing important implications for age-related neurological conditions.

10 citations
Region‐specific sex modulation of central oxytocin receptor by gut microbiota: An ontogenic study
Developmental Neurobiology 81 (2), 149-163 (2021) | Effah F, de Gusmao Taveiros Silva NK, Camarini R, Joly F, Rabot S, et al.

Summary

This study explores how gut microbiota influences oxytocin receptors in the brain differently based on sex, revealing important connections in the gut-brain axis during development.

8 citations
HA-MOP knockin mice express the canonical µ-opioid receptor but lack detectable splice variants
Communications Biology 4 (1), 1070 (2021) | Fritzwanker S, Moulédous L, Mollereau C, Froment C, Burlet-Schiltz O, et al.

Summary

This study characterizes a new mouse model for studying µ-opioid receptors, providing valuable insights for research on pain management and addiction.

6 citations
Sex‐dependent impact of microbiota status on cerebral μ‐opioid receptor density in fischer rats
European Journal of Neuroscience 55 (8), 1917-1933 (2022) | Effah F, de Gusmão Taveiros Silva NK, Vijayanathan K, Camarini R, et al.

Summary

This research reveals how gut microbiota differently affects opioid receptors in the brain based on sex, with implications for pain perception and addiction vulnerability.

0 citations
Differential temporal decline of cerebral oxytocin and μ‐opioid receptor density during the aging process in mice
European Journal of Neuroscience 60 (11), 6686-6703 (2024) | Effah F, Nidadavolu P, de Gusmão Taveiros Silva NK, Wojtowicz M, et al.

Summary

This research tracks how oxytocin and opioid receptors change differently with age in the brain, providing insights into age-related changes in social behavior and pain perception.

0 citations
Age-related decline in density of μ-opioid and oxytocin receptors in the mouse brain: P041
British Journal of Pharmacology 178 (24), 4959-4960 (2021) | Wojtowicz M, Effah F, Bailey A

Summary

This study documents how important brain receptors decrease with age, contributing to our understanding of age-related changes in pain perception and social behavior.

0 citations
The influence of gut microbiota on cerebral oxytocin receptor (OTR) and m-opioid receptor (MOPr) ontogeny in the rat
(2020) | Effah F, de Gusmao Taveiros Silva NK, Camarini R, Joly F, Rabot S, et al.

Summary

This early research explores how gut bacteria influence the development of important brain receptors, laying groundwork for understanding the gut-brain connection.

3D Lung Modelling

11 citations
Toxicological assessment of E-cigarette flavored E-liquids aerosols using Calu-3 cells: a 3D lung model approach
Toxicology 500, 153683 (2023) | Effah F, Adragna J, Luglio D, Bailey A, Marczylo T, Gordon T

Summary

This research utilizes advanced 3D lung models to evaluate the toxicological effects of flavored e-cigarette aerosols, providing more physiologically relevant insights than traditional cell culture methods.

Toxicology

1 citation
Emerging nicotine analog 6-methyl nicotine increases reactive oxygen species in aerosols and cytotoxicity in human bronchial epithelial cells
Toxicology Letters (2025) | Effah F, Sun Y, Friedman A, Rahman I

Summary

This cutting-edge research examines how a new nicotine alternative increases harmful oxidative stress and cell damage in lung cells, raising concerns about its safety.

0 citations
A comparative toxicological evaluation of emerging nicotine analogs 6-methyl nicotine and nicotinamide: a scoping review
Archives of Toxicology 1-8 (2025) | Effah F, Sun Y, Lin K, Rahman I

Summary

This review compares the toxicity profiles of two emerging nicotine alternatives, providing crucial information for regulators and public health officials.

0 citations
Genetic diversity leads to differential inflammatory responses to cigarette smoke in mice
Physiological Reports 13 (2), e70199 (2025) | Faizan MI, Kaur G, Shaikh SB, Effah F, Unwalla H, Rahman I

Summary

This study demonstrates how genetic differences influence inflammatory responses to cigarette smoke, explaining why some individuals may be more susceptible to smoking-related diseases.